[2008-2009]  [2010-2011]  [2012- 2013]

伴侶動物学研究室から発表した最近の論文です。

Watarai A, Arai N, Miyawaki S, Okano H, Miura K, Mogi K, Kikusui T. Responses to pup vocalizations in subordinate naked mole-rats are induced by estradiol ingested through coprophagy of queen's feces. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9264-9269. doi: 10.1073/pnas.1720530115. Epub 2018 Aug 27.

Akitsugu Konno, Miho Inoue-Murayama, Shinji Yabuta, Akiko Tonoike, Miho Nagasawa, Kazutaka Mogi, Takefumi Kikusui. Effect of Canine Oxytocin Receptor Gene Polymorphism on the Successful Training of Drug Detection Dogs. J Hered. 2018 Jun 27;109(5):566-572. doi: 10.1093/jhered/esy012.

Mai Tsunoda, Kazunari Miyamichi, Ryo Eguchi, Yasuo Sakuma, Yoshihiro Yoshihara, Takefumi Kikusui, Masayoshi Kuwahara, and Kazushige Touhara.　Identification of an intra- and inter-specific tear protein signal in rodents.　Curr Biol. 2018 Apr 23;28(8):1213-1223.e6. doi: 10.1016/j.cub.2018.02.060. Epub 2018 

Kikusui T, Kajita M, Otsuka N, Hattori T, Kumazawa K, Watarai A, Nagasawa M, Inutsuka A, Yamanaka A, Matsuo N, Covington HE, Mogi K. Sex differences in olfactory-induced neural activation of the amygdala. Behav Brain Res. 2018 Jul 2;346:96-104. doi: 10.1016/j.bbr.2017.11.034. Epub 2017 Dec 

Hattori T, Osakada T, Masaoka T, Ooyama R, Horio N, Mogi K, Nagasawa M, Haga-Yamanaka S, Touhara K, Kikusui T. Exocrine Gland-Secreting Peptide 1 Is a Key Chemosensory Signal Responsible for the Bruce Effect in Mice. Curr Biol. 2017 Oct 23;27(20):3197-3201.e3.

Miho Nagasawa, Misato Ogawa, Kazutaka Mogi, Takefumi Kikusui. Intranasal Oxytocin Treatment Increases Eye-Gaze Behavior toward the Owner in Ancient Japanese Dog Breeds. Frontiers in Psychology, section Comparative Psychology. , 21 https://doi.org/10.3389/fpsyg.2017.01624                  

Asaba A, Mogi K, Kikusui T. Male mice ultrasonic vocalizations enhance female sexual approach and hypothalamic kisspeptin neuron activity. Horomones and Behavior. 2017 Aug;94:53-60. doi: 10.1016/j.yhbeh.2017.06.006.

Yumiko Yamazaki; Shinpei Kawarai; Hidetoshi Morita; Takefumi Kikusui; Atsushi Iriki　Faecal transplantation for the treatment of Clostridium difficile infection in a marmoset. BMC Veterinary Research, 201713:150 DOI: 10.1186/s12917-017-1070-z

Harumi Saito, Hirofumi Nishizumi, Satoshi Suzuki, Hideyuki Matsumoto, Nao Ieki, Takaya Abe, Hiroshi Kiyonari, Masahiko Morita, Hideo Yokota, Nozomi Hirayama, Takahiro Yamazaki, Takefumi Kikusui, Kensaku Mori, and Hitoshi Sakano. Immobility responses are induced by photoactivation of single glomerular species responsive to fox odor TMT. Nature Communication 2017 Jul 7;8:16011. doi: 10.1038/ncomms16011.

Kasumi Inokuchi , Fumiaki Imamura , Haruki Takeuchi , Ryang Kim , Hiroyuki Okuno , Hirofumi Nishizumi , Haruhiko Bito, Takefumi Kikusui, Hitoshi Sakano. Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odor-induced attractive social responses. Nature Communication 2017 Jul 21;8:15977. doi: 10.1038/ncomms15977.

Shota Okabe, Yousuke Tsuneoka, Aki Takahashi, Rumi Oyama, Akiyuki Watarai, Sayaka Maeda, Yuka Honda, Miho Nagasawa, Kazutaka Mogi, Katsuhiko Nishimori, Masaru Kuroda, Tsuyoshi Koide, Takefumi Kikusui.  Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice. Psychoneuroendocrinology. 2017 May;79:20-30.

Hiroi N, Kikusui T. A self-generated environmental factor as a potential contributor to atypical early social communication in autism. Neuropsychopharmacology Reviews. 2017 Jan;42(1):378.

Mogi K, Takakuda A, Tsukamoto C, Oyama R, Okabe S, Koshida N, Nagasawa M, Kikusui T. Mutual mother-infant recognition in mice: the role of pup ultrasonic vocalizations. Behavioral Brain Research,  2017 May 15;325(Pt B):138-146.

Takefumi Kikusui, Yukino Ishio, Miho Nagasawa, Jeffrey Mogil, Kazutaka Mogi. Early weaning impairs a social contagion of pain-related stretching behavior in mice. Developmental Psychobiology, 2016 Dec;58(8):1101-1107

Kazutaka Mogi, Yuiko Ishida, Miho Nagasawa, Takefumi Kikusui. Early weaning impairs fear extinction and decreases brain-derived neurotrophic factor expression in the prefrontal cortex of adult male C57BL/6 mice. Developmental Psychobiology,2016  58, 1034-1042, 

Maki Katayama, Takatomi Kubo, Kazutaka Mogi, Kazushi Ikeda, Miho Nagasawa, Takefumi Kikusui. Heart rate variability predicts the emotional state in dogs. Behavioral Processes, Volume 128, July 2016, Pages 108–112

Tatsuya Hattori, Takuya Osakada, Ayaka Matsumoto, Naoki Matsuo, Sachiko Haga-Yamanaka, Takaya Nishida, Yuji Mori, Kazutaka Mogi, Kazushige Touhara, Takefumi Kikusui "Self-Exposure to the Male Pheromone ESP1 Enhances Male Aggressiveness in Mice". Current Biology, Volume 26, Issue 9, p1229–1234, 9 May 2016. 

Midori Ohkita, Miho Nagasawa, Mogi Kazutaka, and Takefumi Kikusui Owners' direct gazes increase dogs' attention-getting behaviors. Behavioral Processes. Volume 125, April 2016, Pages 96–100

Hiroshi Yamaguchi, Keiko Wada, Miho Nagasawa, Takefumi Kikusui, Hitomi Sakai, Masami Mizobuchi, Seiji Yoshimoto, Hideto Nakao, Very Low Birth Weight Monochorionic Diamniotic Twins as a Risk Factor for Symptomatic Patent Ductus Arteriosus. Neonatology Vol. 109, No. 3, 2016

Misako Takagi, Akiyo Nakano, Hidehiro Toh, Kenshiro Oshima, Kensuke Arakawa, Fumihiko Nakajima, Kosuke Tashiro, Takefumi Kikusui, Fujitoshi Yanagida, and Hidetoshi Morita　Draft genome sequence of Streptococcus orisasini SH06 isolated from a healthy thoroughbred gastrointestinal tract. Genome Announcements (genomeA) 2016 Jan 14;4(1). pii: e01566-15.

Akiko Tonoike, Miho Nagasawa, Kazutaka Mogi, James Serpell, Hisashi Ohtsuki, and Takefumi Kikusui Comparison of owner-reported behavioral characteristics among genetically clustered breeds of dog (Canis familiaris). Scientific Reports, 5, 17710, 2015.

Miho Nagasawa, Kazutaka Mogi, James Serpell, and Takefumi Kikusui Comparison of behavioral characteristics of dogs in the United States and Japan. J Vet Med Sci,J Vet Med Sci, 2016 78(2):231-8.

T. Takahashi, S. Okabe, P. Ó Broin, A. Nishi, K. Ye, M. V. Beckert, T. Izumi, A. Machida, G. Kang, Seiji Abe, J. L. Pena, A. Golden, T. Kikusui, N. Hiroi. Structure and function of neonatal social communication in a genetic mouse model of autism.  Molecular Psychiatry, 2015 doi:10.1038/mp.2015.190.

Hidehiro Toh, Yumiko Yamazaki, Kosuke Tashiro, Shinpei Kawarai, Kenshiro. Oshima, Akiyo Nakano, Co Nguyen Thi Kim, Iyo Mimura, Kensuke Arakawa, Atsushi Iriki, Takefumi Kikusui, Hidetoshi Morita. Draft genome sequence of Bifidobacterium aesculapii DSM 26737T isolated from feces of baby common marmoset. Genome Announcements,2015 Dec 10;3(6). pii: e01463-15.

Takita M, Kikusui T. Early weaning influences short-term synaptic plasticity in the medial prefrontal-anterior basolateral amygdala pathway. Neurosci Res. 2015 Aug 31. pii: S0168-0102(15)00210-2. doi: 10.1016/j.neures.2015.08.003. 

A. Tonoike, Y. Hori, M. Inoue-Murayama, A. Konno, K. Fujita, M. Miyado, M. Fukami, M. Nagasawa, K. Mogi, T. Kikusui.　Copy number variations in the amylase gene in Japanese native dog breeds Anim Genet. 2015 Oct;46(5):580-3. doi: 10.1111/age.12344.

Asaba A, Kato M, Koshida N, Kikusui T. Determining Ultrasonic Vocalization Preferences in Mice using a Two-choice Playback Test. J Vis Exp. 2015 Sep 3;(103). doi: 10.3791/53074.

Ode M, Asaba A, Miyazawa E, Mogi K, Kikusui T, Izawa E. Sex-reversed correlation between stress levels and dominance rank in a captive non-breeder flock of crows. Horm Behav. 2015 Jul;73:131-4. doi: 10.1016/j.yhbeh.2015.07.012. 

Oguchi M, Okajima M, Tanaka S, Koizumi M, Kikusui T, Ichihara N, Kato S, Kobayashi K, Sakagami M. Double Virus Vector Infection to the Prefrontal Network of the Macaque Brain. PLoS One. 2015 Jul 20;10(7):e0132825. doi: 10.1371/journal.pone.0132825. 

Nagasawa M, Mitsui S, En S, Ohtani N, Ohta M, Sakuma Y, Onaka T, Mogi K, Kikusui T. Oxytocin-gaze positive loop and the coevolution of human-dog bonds.  Science. 2015 Apr 17;348(6232):333-6. doi: 10.1126/science.1261022.

Romero T, Nagasawa M, Mogi K, Hasegawa T, Kikusui T. Intranasal administration of oxytocin promotes social play in domestic dogs. Communicative & Integrative Biology. 8, 3, 2015.

Matsuo T, Hattori T, Asaba A, Inoue N, Kanomata N, Kikusui T, Kobayakawa R, Kobayakawa K. Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):E311-20. doi: 10.1073/pnas.1416723112. 

Kazutaka Mogi, Haruka Takanashi, Miho Nagasawa, and Takefumi Kikusui Sex differences in spatiotemporal expression of AR, ERα, and ERβ mRNA in the perinatal mouse brain. Neurosci Lett. 2015 Jan 1;584:88-92. doi: 10.1016/j.neulet.2014.10.028.

Misato Yasumura, Tomoyuki Yoshida, Maya Yamazaki, Manabu Abe, Rie Natsume, Kouta Kanno, Takeshi Uemura, Keizo Takao, Kenji Sakimura, Takefumi Kikusui, Tsuyoshi Miyakawa & Masayoshi Mishina IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours. Scientific Reports, 4, Article number: 6613 doi:10.1038/srep06613

Hattori T, Kanno T, Nagasawa M, Nishimori K, Mogi K, Kikusui T. Impairment of interstrain social recognition during territorial aggressive behavior in oxytocin receptor-null mice. Neurosci Res. 2015 Jan;90:90-4. doi: 10.1016/j.neures.2014.05.003. 

Asaba A, Hattori T, Mogi K, Kikusui T.  Sexual attractiveness of male chemicals and vocalizations in mice. Front Neurosci. 2014 Aug 5;8:231. doi: 10.3389/fnins.2014.00231. 

Saito A, Hamada H, Kikusui T, Mogi K, Nagasawa M, Mitsui S, Higuchi T, Hasegawa T, Hiraki K. Urinary oxytocin positively correlates with performance in facial visual search in unmarried males, without specific reaction to infant face.　Front Neurosci. 2014 Jul 29;8:217. doi: 10.3389/fnins.2014.00217. eCollection 2014.

Mogi, M., Ooyama, R., Nagasawa, M., Kikusui, T. Effects of neonatal oxytocin manipulation on development of social behaviors in mice. Physiol. Behav. 133, 68–75, 2014.

Romero T, Nagasawa M, Mogi K, Hasegawa T, Kikusui T.　Oxytocin promotes social bonding in dogs. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9085-90. 

オキシトシンは哺乳類では視床下部で産生され、母子間や雌雄間の絆形成において重要な役割を担うホルモンである。ヒトにおいては絆形成に加えて、信頼や寛大さ等のより複雑な協力行動の促進にも関与している。今回の東京大学と麻布大学の共同研究では、オキシトシンがイヌと彼らの飼い主および同居犬との親和的関係の維持にも関与していることが示された。

本研究には16頭のイヌとその飼い主および同居犬が参加した。それぞれのイヌにはオキシトシンあるいは生理的食塩水が経鼻投与され、その後に飼い主と同居犬と一緒に過ごした間の行動が観察された。オキシトシンを投与されたイヌは生理的食塩水投与に比べてより多くの向社会行動を示し、特に飼い主に対する高い志向性と親和性、同居犬に対する高い親和性がみられた。本研究の結果は、イヌにおいてオキシトシンが母子間や雌雄間の絆とは異なる親和的関係の形成に関与していることを示唆している。社会的関係の量と質は、ヒトでも動物でも寿命や子孫の生存に影響することから、これは非常に重要な発見である。また、オキシトシンは社会的な協調性や機能に障害をもつ人達に対する有望な治療薬の候補になりうると期待される。

Asaba A, Okabe S, Nagasawa M, Kato M, Koshida N, Osakada T, Mogi K, Kikusui T.　Developmental social environment imprints female preference for male song in mice. PLoS One. 2014 Feb 5;9(2):e87186. doi: 2014.

いくつかの動物では、雄と雌が出会った際に、求愛ディスプレーとして、雄からの積極的な歌が観察されます。例えば、鳥のさえずりなどが有名で、この歌を聴くことで雌は雄の良し悪しを判断して、交配相手を選びます。近年、雄マウスが雌に出会うと、ヒトには聞こえない超音波領域で鳥類が歌うような「歌」構造を持つ音声を発することが報告されました。この雄の求愛歌には系統による違いが存在することが分かっていましたが、この歌を雌マウスがどのように感じているのかは明らかにされていませんでした。

本研究では、２つの系統の雄の歌を同時に再生し、雌の歌への接近時間を調べることにより、雌が、自身の系統ではない他の系統の雄が発する歌をより好むことを明らかにしました。このような血縁動物との交配を回避する現象は、ヒトを含め、様々な生物で認められています。さらに、歌の好みは、雌の生まれ育った環境を２系統間で入れ替える里子操作や、父親がいない環境で育てることで変化したことから、父親の歌を幼少期に覚えることによって身に付くことがわかりました。また、歌への好みを示すには、雄の匂いを一緒に提示することが重要であることもわかり、雌が複数の雄のシグナルを受け取り、意思決定している可能性も見出すことができました。この研究で得られた成果は、動物の雌が好きな雄の歌を聞くことによって、雌の繁殖機能が制御できるという応用的側面での利用が期待できます。

Nagasawa M, Shimozawa A, Mogi K, Kikusui T N-Acetyl-D-Mannosamine Treatment Alleviates Age-Related Decline in Place-Learning Ability in Dogs. J Vet Med Sci. 2014 Jan 16. [Epub ahead of print]